Statement on the Clinical Use of Human Germline Genome Editing
Given that According to the canons of research on children, experiments are only ethically justified when there are clear benefits to that individual child and proportional burdens to that child. Risks and burdens beyond truly “minimal” to individual children are not justified to benefit other children. To do so is to treat one child as a means to another child’s ends (i.e., to instrumentalize that child).
Whereas Human germline genome editing is experimentation on embryonic humans who cannot give consent, ...read more
Life Without Us?
By Jane Patton, Guest Columnist
It is not new that some people say that they do not want to bring children into the world. And, as far as the do’s and don’ts of being environmentally responsible, the carbon footprint of a single human being tops the list of avoidable behaviors. One presidential candidate even advocates abortion as a way to combat climate change. So, it may be okay to have one or two children. Any more than that and parents might be called selfish.
But, a growing movement is taking the idea of limiting births to the next level—preventing all births. Who ...read more
When Can Others Help Themselves to Our Organs?
D. Joy Riley, M.D., M.A. Executive Director
We have an opt-in organ donation system in the United States. That is, you have to say, “Yes,” to organ donation in order to donate. Opting in is very easy, and you can usually do that through your local Department of Motor Vehicles (DMV). Even those too young to vote can opt-in for organ donation. Why is this service available through the DMV? A few moments’ thought can yield an answer.
England has recently changed its law governing organ donation. The new “opt-out” law takes effect in 2020:
Everyone in England over the age of 18 will ...read moreAMA Resists Embracing “Neutrality” on Physician-Assisted Suicide
D. Joy Riley, M.D., M.A. Executive Director
Yesterday, the American Medical Association (AMA) House of Delegates voted to retain the current position of the AMA RE physician-assisted suicide. That was the recommendation of the AMA’s Council on Ethical and Judicial Affairs (CEJA), and the CEJA report was accepted by a 65:35 majority, according to the National Right to Life News.
CEJA is responsible for maintaining and updating the AMA’s Medical Code of Ethics, and promoting “adherence to the Code’s professional ethical standards.” Last year, CEJA recommended maintaining the long-held AMA stance against physician-assisted suicide, but the House of Delegates rejected that recommendation. Further ...read more
A Moratorium on Heritable Human Genome Editing: Illusory or Real?
D. Joy Riley, M.D., M.A. Executive Director
In March, 2019, Nature published a commentary penned by Eric Lander, Françoise Baylis, Feng Zhang, Emmanuelle Charpentier, and Paul Berg, and signed by 13 other notables. The name of the commentary is “Adopt a moratorium on heritable genome editing.” This document requires analysis.
First, some definitions are needed. A moratorium is defined as a “suspension of activity,” or “an authorized period of delay or waiting.” Heritable means “capable of being passed from one generation to the next.” Additionally, clinical can refer to a “scientifically detached” attitude or “the observation and treatment of patients directly.” Each of ...read more
Transgenic Monkeys: Coming to a Lab Near You?
D. Joy Riley, M.D., M.A. Executive Director
The initial draft sequence of the chimpanzee genome was published in September 2005 – in comparison with the human genome. A few months later, geneticist James M. Sikela wrote in PLOS Genetics, “the genes and genetic changes that are responsible for making the human brain what it is and for allowing it to do what it uniquely does, have long been among the most prized jewels of our genome.” In that paper, Sikela considered how one could locate the changes in the genome that account for “human-specific cognitive abilities.” How could one prove that a ...read more
A Book for (Y)our Time – A Review
D. Joy Riley, M.D., M.A. Executive Director
Reading Siddhartha Mukherjee’s The Gene: An Intimate History (NY, NY: Scribner, 2016; paperback, 2017) is to take a 150+ year print journey with an English-speaking physician and scientist, who is also a renaissance man. Mukherjee, an assistant professor of medicine at Columbia University, won the Pulitzer Prize in 2011 for his non-fiction work, The Emperor of All Maladies: A Biography of Cancer. I have not read that earlier work, but have spent time delving into The Gene.
The Gene: An Intimate History begins with the author’s 2012 trip to Calcutta with his father to visit a ...read more
Shift and Puzzle: What do an ape and a donkey have to do with bioethics?
D. Joy Riley, M.D., M.A. Executive Director
In C. S. Lewis’ The Last Battle, Shift is a shrewd, crafty ape, and his neighbor, Puzzle, is a meek, somewhat simple donkey. It has been a long time since Aslan, the all-powerful lion, has been seen in Narnia. Therefore, when Shift spies an old lion skin, he decides to have Puzzle dress up in it and pretend to be Aslan. Shift constantly insists that Puzzle do all the heavy-lifting involved in any of their escapades, but in such a way that Puzzle thinks he is getting the ...read more
What Say You?
Update: See the bottom of this post for the National Institutes of Health’s response to our letter.
An Open Letter to Dr. Francis S. Collins, Director of the National Institutes of HealthD. Joy Riley, M.D., M.A. Executive Director
Francis S. Collins, M.D., Ph.D. Director National Institutes of Health 9000 Rockville Pike Bethesda, Maryland 20892 execsec1@od.nih.gov
17 December 2018
Dear Dr. Collins:
The Tennessee Center for Bioethics & Culture lauds the position of the National Institutes of Health (NIH) as evidenced by your concluding statement of 28 November 2018: “NIH does not support the use of gene-editing technologies in human embryos.” As embryonic humans represent the most vulnerable amongst our species, the ...read more
