Editing Our Future
The recent (March 6-8, 2023) meeting of the Third International Summit on Human Genome Editing in London has brought ethical concerns about heritable human genome editing to the forefront once again. Recall that the previous meeting five years ago exploded into international furor over revelations from He Jiankui, the Chinese scientist who edited the genomes of three embryos and brought them to term. He was jailed for his actions in China and was only recently released. Apparently, he is unrepentant and still harboring visions of reactivating his genome editing pursuits. Not surprisingly, ...read more
GATTACA: 25 Years On
Joyce A. Shelton, Ph.D. Professor of Biology Emerita Trinity International University
(Editor’s Note: The Tennessee Center for Bioethics & Culture screened GATTACA at the end of June at the international bioethics conference held by the Center for Bioethics & Human Dignity at Trinity International University. Dr. Shelton presented opening remarks, which, lightly edited, are presented here.)
The movie, GATTACA, is entertaining to watch as is, but is also rife with symbolism and subtle—and some not so subtle—philosophical messages. 25 years on: it has proved to be prescient in a number of ways.
GATTACA depicts a dystopian world in which there is a new type of social ...read more
Who is He and what has he done to our children?
Joyce A. Shelton, Ph.D. Professor of Biology Emerita Trinity International University
Remember He Jiankui? He is the Chinese scientist who used CRISPR technology to edit the CCR5 gene for the HIV receptor in the genomes of human embryos. His goal was to make them HIV resistant. He reported at an international conference in 2018 that two of the edited embryos had resulted in the live births of non-identical twins, Nana and Lulu. There were also reports of a third child born in 2019. His revelations in a public forum provoked moral outrage from the scientific community. Global pressure caused Chinese authorities to suspend ...read more
What We’re Reading
www.CartoonStock.com
C. Ben Mitchell, Ph.D. Distinguished Fellow
Medically assisted deaths rose by 17% in 2020, continuing upward trend: Health CanadaBy Joan Bryden The Canadian Press Posted June 8, 2021 1:01 am
I have several concerns about this situation:
For Health Canada, the government health service, to provide access to P-AS is a financial conflict of interest. Medicalized suicide should not be in the hands of those who hold the purse strings. Pain is manageable but other forms of suffering are not best treated with analgesics. True palliative care must address all forms of suffering. Medicine should not be coopted by the P-AS ...read moreStatement on the Clinical Use of Human Germline Genome Editing
Given that According to the canons of research on children, experiments are only ethically justified when there are clear benefits to that individual child and proportional burdens to that child. Risks and burdens beyond truly “minimal” to individual children are not justified to benefit other children. To do so is to treat one child as a means to another child’s ends (i.e., to instrumentalize that child).
Whereas Human germline genome editing is experimentation on embryonic humans who cannot give consent, ...read more
A Moratorium on Heritable Human Genome Editing: Illusory or Real?
D. Joy Riley, M.D., M.A. Executive Director
In March, 2019, Nature published a commentary penned by Eric Lander, Françoise Baylis, Feng Zhang, Emmanuelle Charpentier, and Paul Berg, and signed by 13 other notables. The name of the commentary is “Adopt a moratorium on heritable genome editing.” This document requires analysis.
First, some definitions are needed. A moratorium is defined as a “suspension of activity,” or “an authorized period of delay or waiting.” Heritable means “capable of being passed from one generation to the next.” Additionally, clinical can refer to a “scientifically detached” attitude or “the observation and treatment of patients directly.” Each of ...read more
A Book for (Y)our Time – A Review
D. Joy Riley, M.D., M.A. Executive Director
Reading Siddhartha Mukherjee’s The Gene: An Intimate History (NY, NY: Scribner, 2016; paperback, 2017) is to take a 150+ year print journey with an English-speaking physician and scientist, who is also a renaissance man. Mukherjee, an assistant professor of medicine at Columbia University, won the Pulitzer Prize in 2011 for his non-fiction work, The Emperor of All Maladies: A Biography of Cancer. I have not read that earlier work, but have spent time delving into The Gene.
The Gene: An Intimate History begins with the author’s 2012 trip to Calcutta with his father to visit a ...read more
What Say You?
Update: See the bottom of this post for the National Institutes of Health’s response to our letter.
An Open Letter to Dr. Francis S. Collins, Director of the National Institutes of HealthD. Joy Riley, M.D., M.A. Executive Director
Francis S. Collins, M.D., Ph.D. Director National Institutes of Health 9000 Rockville Pike Bethesda, Maryland 20892 [email protected]
17 December 2018
Dear Dr. Collins:
The Tennessee Center for Bioethics & Culture lauds the position of the National Institutes of Health (NIH) as evidenced by your concluding statement of 28 November 2018: “NIH does not support the use of gene-editing technologies in human embryos.” As embryonic humans represent the most vulnerable amongst our species, the ...read more
The Rubicon
D. Joy Riley, M.D., M.A. Executive Director
The law in the Roman Republic in 49 B.C. was very clear about an army crossing a small stream outside Rome: it was considered an act of war. Julius Caesar knew this, and led his 13th Legion across that stream, declaring, in the historian Suetonius’ words, “The die is cast!” Caesar and his army did not turn back, but continued on to war, and ultimately defeated Pompey the Great. This turning point in history is referenced whenever we talk about approaching a point of no return and utter the phrase, “crossing the Rubicon.”
“The Rubicon” sculpture ...read more
It Has Arrived: Gene Editing Recommendations Published
D. Joy Riley, M.D., M.A. Executive Director
The committee appointed to advise our government regarding the editing of genes, including editing the genes of the human embryo, has published a draft report (see the title page screen shot above). We at The Tennessee Center for Bioethics & Culture are studying the document’s 261 pages, and have a few caveats to share with our readers. Germline gene editing was given cautious approval by the committee:
Heritable germline genome editing trials must be approached with caution, but caution does not mean they must be prohibited. (p. 102)
and
If the technical challenges are ...read more
