23andMe: The Gift That Keeps on Giving
23andMe is a leading provider of personalized genetic testing (screen shot of product above). For $229 and a test tube of spit, anyone can have their DNA analyzed and receive direct reports on their ancestry, genetic traits, health risks and pre-dispositions, carrier risks and more. Consumers are also invited to share their genetic information with relatives and healthcare professionals and they can choose to have their “de-identified” data shared with pharmaceutical and medical research companies for the development of new drugs and treatments. About 80% of consumers agree to share their personal ...read more
GATTACA: 25 Years On
Joyce A. Shelton, Ph.D. Professor of Biology Emerita Trinity International University
(Editor’s Note: The Tennessee Center for Bioethics & Culture screened GATTACA at the end of June at the international bioethics conference held by the Center for Bioethics & Human Dignity at Trinity International University. Dr. Shelton presented opening remarks, which, lightly edited, are presented here.)
The movie, GATTACA, is entertaining to watch as is, but is also rife with symbolism and subtle—and some not so subtle—philosophical messages. 25 years on: it has proved to be prescient in a number of ways.
GATTACA depicts a dystopian world in which there is a new type of social ...read more
Who is He and what has he done to our children?
Joyce A. Shelton, Ph.D. Professor of Biology Emerita Trinity International University
Remember He Jiankui? He is the Chinese scientist who used CRISPR technology to edit the CCR5 gene for the HIV receptor in the genomes of human embryos. His goal was to make them HIV resistant. He reported at an international conference in 2018 that two of the edited embryos had resulted in the live births of non-identical twins, Nana and Lulu. There were also reports of a third child born in 2019. His revelations in a public forum provoked moral outrage from the scientific community. Global pressure caused Chinese authorities to suspend ...read more
Guinea Pigs
Joyce A. Shelton, Ph.D. Professor of Biology Emerita Trinity International University
Successful xenotransplantation, animal donor to human recipient organ transfer, is the holy grail for medical doctors and scientists who study organ transplant. Why? Approximately 107,000 people are awaiting organ transplant in the US. Most will wait up to 2 to 3 years. About 17 people die per day because there are not enough organs available to meet the demand (1). Animal organs that have been genetically engineered to remove tissue molecules that cause transplant rejection would go a long way toward relieving the organ shortage.
A recently proclaimed major transplantation breakthrough attracted widespread ...read more
What We’re Reading
www.CartoonStock.com
C. Ben Mitchell, Ph.D. Distinguished Fellow
Medically assisted deaths rose by 17% in 2020, continuing upward trend: Health CanadaBy Joan Bryden The Canadian Press Posted June 8, 2021 1:01 am
I have several concerns about this situation:
For Health Canada, the government health service, to provide access to P-AS is a financial conflict of interest. Medicalized suicide should not be in the hands of those who hold the purse strings. Pain is manageable but other forms of suffering are not best treated with analgesics. True palliative care must address all forms of suffering. Medicine should not be coopted by the P-AS ...read moreThe Prescription for Flourishing Embodiment in Public Bioethics
A Book Review
C. Ben Mitchell, Ph.D. Distinguished Fellow
American public bioethics does not have a sterling history because it misunderstands its most important subject, the human subject. This is the claim of a brilliant new book by O. Carter Snead, the Director of the de Nicola Center for Ethics and Culture and professor of Political Science at the University of Notre Dame.
In What it Means to be Human: The Case for the Body in Public Bioethics (Harvard, 2020), Snead offers a genealogy of American public bioethics. Public bioethics, as contrasted with clinical bioethics, is the realm of human subjects research where, instead ...read more
The Problem of Ill-Gotten Gain in Health Care
C. Ben Mitchell, Ph.D. Distinguished Fellow
The politicized debate about President Trump’s treatment for Covid-19 may have shrouded an important set of questions about the science of developing treatments, viz., the problem of ill-gotten gain.
Among other treatment protocols, the President received Regeneron’s REGN-COV2, a “cocktail” of two neutralizing antibodies that has shown promise in some animal studies (see here and here). The media jumped on an association between REGN-COV2 antibodies and fetal cells, some even claiming that the antibodies were developed from fetal cells.
Screenshot of NYT headline on Oct. 8, 2020
The fact of the matter is REGN-COV2 was tested for its virus-neutralizing ...read more
23andMe and Drug Development
D. Joy Riley, M.D., M.A. Executive Director
More than a decade ago—in a different time and a different place—a neighbor offered me a box of stuff he had bought as part of a lot at some estate sale. He needed to get rid of no small amount of “stuff,” so he gave me that box of tarnished silverware and odds and ends. I took it home and spent a couple of days cleaning it. We were already planning a yard sale, and so I placed the now-cleaned items I did not need from the neighbor’s box in the sale. Imagine his surprise ...read more
A Moratorium on Heritable Human Genome Editing: Illusory or Real?
D. Joy Riley, M.D., M.A. Executive Director
In March, 2019, Nature published a commentary penned by Eric Lander, Françoise Baylis, Feng Zhang, Emmanuelle Charpentier, and Paul Berg, and signed by 13 other notables. The name of the commentary is “Adopt a moratorium on heritable genome editing.” This document requires analysis.
First, some definitions are needed. A moratorium is defined as a “suspension of activity,” or “an authorized period of delay or waiting.” Heritable means “capable of being passed from one generation to the next.” Additionally, clinical can refer to a “scientifically detached” attitude or “the observation and treatment of patients directly.” Each of ...read more
Transgenic Monkeys: Coming to a Lab Near You?
D. Joy Riley, M.D., M.A. Executive Director
The initial draft sequence of the chimpanzee genome was published in September 2005 – in comparison with the human genome. A few months later, geneticist James M. Sikela wrote in PLOS Genetics, “the genes and genetic changes that are responsible for making the human brain what it is and for allowing it to do what it uniquely does, have long been among the most prized jewels of our genome.” In that paper, Sikela considered how one could locate the changes in the genome that account for “human-specific cognitive abilities.” How could one prove that a ...read more
